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| 購(gòu)買(mǎi)進(jìn)口儀器、試劑和耗材——就在始于2001年的畢特博生物 www.kjhfd.cn |
美國(guó)芝加哥大學(xué)等處的研究人員發(fā)現(xiàn)，飼養(yǎng)于無(wú)菌環(huán)境或剛出生時(shí)給予抗生素的老鼠，缺乏一種似乎可預(yù)防食物過(guò)敏的常見(jiàn)腸道細(xì)菌。相關(guān)文章發(fā)表于2014年8月25日的《PNAS》雜志上。 這種稱為梭狀芽孢桿菌(Clostridia)的細(xì)菌，似乎可減少老鼠對(duì)花生過(guò)敏的可能性，研究人員希望探究對(duì)人類(lèi)是否也如此。 同時(shí)，根據(jù)刊登于美國(guó)《國(guó)家科學(xué)院學(xué)報(bào)(Proceedings of the National Academy of sciences)》的報(bào)告，研究人員發(fā)現(xiàn)，在老鼠長(zhǎng)大后給予含有梭狀芽孢桿菌的益生菌，可能扭轉(zhuǎn)過(guò)敏情況。 美國(guó)芝加哥大學(xué)(University of Chicago)食物過(guò)敏教授、資深研究作者納格勒(Cathryn Nagler)表示：“諸如過(guò)度使用抗生素、高脂肪飲食、剖腹產(chǎn)、移除常見(jiàn)病原體、甚至是配方喂養(yǎng)，都會(huì)影響與我們共同演化出來(lái)的微生物。” 納格勒說(shuō)：“從我們的研究結(jié)果可得知，這會(huì)增加對(duì)食物過(guò)敏的機(jī)率。” 原文摘要： Commensal bacteria protect against food allergen sensitization Andrew T. Stefka, Taylor Feehley, Prabhanshu Tripathi, Ju Qiu, Kathy McCoy,Sarkis K. Mazmanian, Melissa Y. Tjota, Goo-Young Seo, Severine Cao, Betty R. Theriault,Dionysios A. Antonopoulos, Liang Zhou, EuGENE B. Chang, Yang-Xin Fu and Cathryn R. Nagler Environmentally induced alterations in the commensal microbiota have been implicated in the increasing prevalence of food allergy. We show here that sensitization to a food allergen is increased in mice that have been treated with antibiotics or are devoid of a commensal microbiota. By selectively colonizing gnotobiotic mice, we demonstrate that the allergy-protective capacity is conferred by a Clostridia-containing microbiota. Microarray analysis of intestinal epithelial cells from gnotobiotic mice revealed a previously unidentified mechanism by which Clostridia regulate innate lymphoid cell function and intestinal epithelial permeability to protect against allergen sensitization. Our findings will inform the development of novel approaches to prevent or treat food allergy based on modulating the composition of the intestinal microbiota. |
購(gòu)買(mǎi)進(jìn)口儀器、試劑和耗材——就在始于2001年的畢特博生物
www.kjhfd.cn |
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