<var id="29ubh"><small id="29ubh"></small></var>

  • <samp id="29ubh"><acronym id="29ubh"></acronym></samp>

      国产精品久久久久久不卡_欧美激情精品久久_99久久免费精品国产72精品九九_精品熟人妻一区二区三区四区不卡_国产麻豆精品一区二区三区

      ?
      生物資訊

      PLoS ONE:西安交大博士生利用生物微流體力學模型研究牙齒冷熱疼痛區(qū)別機制

      作者:admin 來源:西安交通大學 發(fā)布時間: 2011-04-01 16:17  瀏覽次數:
      購買進口儀器、試劑和耗材——就在始于2001年的畢特博生物 www.kjhfd.cn

      西安交通大學航天學院研究論文“Fluid Mechanics in Dentinal Microtubules Provides Mechanistic Insights into the Difference between Hot and Cold Dental Pain”在國際著名學術刊物《公共科學圖書館—綜合》(PLoS ONE)上發(fā)表。

       

      該論文是航天學院生物醫(yī)學工程與生物力學研究中心博士生林敏,在導師盧天健教授和哈佛大學醫(yī)學院徐峰博士共同指導下,與能動學院白博峰教授合作完成,被PLoS ONE主編確認為不需要外審就可接收的論文。該項研究得到了國家杰出青年科學基金及國家外專局/教育部學科創(chuàng)新引智計劃項目的共同資助。

      冷刺激能快速誘發(fā)短暫的牙痛感(銳痛),而熱刺激則需要延遲一段時間才能產生持久的疼痛感(鈍痛),這一現象眾所周知,但背后的隱藏的機理卻始終是個迷。學術界至今無法對冷熱刺激引起的牙疼痛機理作出令人滿意的定量或是定性解釋。該篇論文作者針對這一難題,提出了交叉學科的研究方法,利用生物微流體力學模型模擬冷熱刺激下牙本質微管內體液的定向流動對牙髓神經末梢的剪切力,并提出修正的Hodgkin-Huxley神經動力學模型,模擬在剪切力作用下,位于神經末梢傷害性感受器上機械敏感性離子通道的開放特性以及神經元放電信號,并與已有的實驗結果相吻合。該研究在國際上首次揭示了牙齒冷熱疼痛的區(qū)別機制,并給出了定量化研究,提出的模型可以預測傷害性刺激引起牙痛強度,并據此來評價、優(yōu)化口腔臨床診療方法,為臨床口腔鎮(zhèn)痛治療提供了理論支持。


      相關結構

      推薦原文出處:

      PLoS ONE 6(3): e18068. doi:10.1371/journal.pone.0018068

      Fluid Mechanics in Dentinal Microtubules Provides Mechanistic Insights into the Difference between Hot and Cold Dental Pain

      Min Lin1, Zheng Yuan Luo2, Bo Feng Bai2, Feng Xu1,3*, Tian Jian Lu1*

      1 School of Aerospace, Biomedical Engineering and Biomechanics Center, Xi'an Jiaotong University, Xi'an, People's Republic of China, 2 State Key Laboratory of Multiphase Flow in Power Engineering, Xi'an Jiaotong University, Xi'an, People's Republic of China, 3 Department of Medicine, HST-Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

      Dental thermal pain is a significant health problem in daily life and dentistry. There is a long-standing question regarding the phenomenon that cold stimulation evokes sharper and more shooting pain sensations than hot stimulation. This phenomenon, however, outlives the well-known hydrodynamic theory used to explain dental thermal pain mechanism. Here, we present a mathematical model based on the hypothesis that hot or cold stimulation-induced different directions of dentinal fluid flow and the corresponding odontoblast movements in dentinal microtubules contribute to different dental pain responses. We coupled a computational fluid dynamics model, describing the fluid mechanics in dentinal microtubules, with a modified Hodgkin-Huxley model, describing the discharge behavior of intradental neuron. The simulated results agreed well with existing experimental measurements. We thence demonstrated theoretically that intradental mechano-sensitive nociceptors are not “equally sensitive” to inward (into the pulp) and outward (away from the pulp) fluid flows, providing mechanistic insights into the difference between hot and cold dental pain. The model developed here could enable better diagnosis in endodontics which requires an understanding of pulpal histology, neurology and physiology, as well as their dynamic response to the thermal stimulation used in dental practices.

      購買進口儀器、試劑和耗材——就在始于2001年的畢特博生物 www.kjhfd.cn

      所有試劑均用于科研 ???? 北京畢特博生物技術有限責任公司 版權所有
      服務熱線:010-82015225/400-833-9299 | 傳真:010-62015131 | E-mail:info@bitebo.com
      京ICP備05028556號-1 ??京公網安備11010802008747??

      亚洲av无码乱码在线观看裸奔_欧美激情精品久久_99久久免费精品国产72精品九九_精品熟人妻一区二区三区四区不卡
      <var id="29ubh"><small id="29ubh"></small></var>

    1. <samp id="29ubh"><acronym id="29ubh"></acronym></samp>
        张北县| 钟山县| 于田县| 丘北县| 北海市| 班戈县| 黎川县| 防城港市| 汶川县| 和平县| 佳木斯市| 金溪县| 南木林县| 青浦区| 含山县| 襄樊市| 常德市| 德惠市| 沙湾县| 五河县| 合作市| 定远县| 大渡口区| 玉山县| 若尔盖县| 象山县| 达孜县| 金沙县| 新郑市| 亳州市| 迭部县| 武宣县| 唐山市| 佛冈县| 措美县| 宕昌县| 柳林县| 盖州市| 肇州县| 寿光市| 秦皇岛市|